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Original Research Article | OPEN ACCESS

Network pharmacology and UPLC-Q-TOF/MS studies on the anti-arthritic mechanism of Pterocephalus hookeri

Ce Tang1, Hai-Jiao Li1, Gang Fan1, Ting-Ting Kuang1, Xian-Li Meng1, Zhong-Mei Zou2, Yi Zhang1

1College of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137; 2Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.

For correspondence:-  Yi Zhang   Email: 1175332408@qq.com   Tel:+862861800074

Accepted: 26 May 2018        Published: 30 June 2018

Citation: Tang C, Li H, Fan G, Kuang T, Meng X, Zou Z, et al. Network pharmacology and UPLC-Q-TOF/MS studies on the anti-arthritic mechanism of Pterocephalus hookeri. Trop J Pharm Res 2018; 17(6):1095-1110 doi: 10.4314/tjpr.v17i6.17

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the mechanism underlying the anti-arthritic properties of Pterocephalus hookeri used for treatment of rheumatoid arthritis (RA).
Methods: Aqueous methanol extract of P. hookeri was analyzed using UPLC-Q-TOF/MS, a Waters Acquity UPLCR BEH C18 column (2.1 × 100 mm, 1.7 μm) and gradient elution with acetonitrile-formic acid-water. Targets and related pathways were predicted by PharmMapper database and Molecule Annotation System, respectively. The network was built with Cytoscape software.
Results: Forty compounds were identified, comprising 17 iridoid glycosides, 7 phenolic acids, 13 triterpenes, and 3 other compounds. A total of 38 targets and 44 pathways associated with RA were obtained. These involved mainly MAPK signaling pathway, adherens junction, and colorectal cancer.
Conclusion: These results from network pharmacology suggest that P. hookeri exerts therapeutic effect on RA via multiple components, multiple targets and multiple pathways.

Keywords: Pterocephalus hookeri, Rheumatoid arthritis, UPLC-Q-TOF/MS, Chemical composition, Network pharmacology

Impact Factor
Thompson Reuters (ISI): 0.523 (2021)
H-5 index (Google Scholar): 39 (2021)

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